Diabetes and Immunology

Diabetes is a disorder which can be caused due to many factors among them immunity is also one of the factors. The destruction of the islet β-cell in T1D is the result of a  complex interplay between multiple players of both the innate and adaptive immune system; immunohistochemical analysis of islet inflammation from pancreata of patients with T1D obtained at autopsy indicate a mononuclear cell infiltrate in islets (termed insulitis) consisting  mainly of macrophages, B cells and T cells. Both CD4+ and CD8+ T cells are required for disease development, by destroying the insulin-producing β cells through the effector functions of Th1 cells and direct killing by cytotoxic T lymphocytes (CTLs). CTLs initiate killing by various mechanisms including the production of inflammatory cytokines such as TNF-a and IFN-g, which act synergistically with IL-1 produced by macrophages in targeting the β-cells; they also directly kill β-cells through the secretion of perforin or by apoptosis by the activation of the Fas-Fas-L pathway.

    Related Conference of Diabetes and Immunology

    November 21-22, 2018

    14th World Congress on Endocrinology & Diabetes

    Paris, France
    November 26-27, 2018

    26th International Diabetes and Healthcare Conference

    Helsinki, Finland
    November 26-27, 2018

    13th European Diabetes and Endocrinology Congress

    Dublin, Ireland
    February 27-28, 2019

    Asia Pacific Diabetes and Endocrinology Congress

    Tokyo, Japan

    April 17-18, 2019

    21st Asia Pacific Diabetes Conference

    Osaka,Japan
    April 29-30, 2019

    2nd Global Meeting on Diabetes and Endocrinology

    Istanbul, Turkey

    28th European Diabetes Congress

    June 10-11, 2019 | Edinburgh, Scotland
    July 24-25, 2019

    29th World Diabetes & Heart Congress

    Melbourne, Australia
    July 29-30, 2019

    12th International Conference on Diabetes & Metabolism

    Chicago | Illinois| USA
    Oct 03-04, 2019

    Euro Diabetes Congress & Expo

    | Paris, France

    Diabetes and Immunology Conference Speakers

    Recommended Sessions

    Related Journals

    Are you interested in