Metabolic Reprogramming in Diabetes

Metabolic reprogramming in diabetes refers to the shift in cellular metabolism that occurs in response to insulin resistance and altered glucose handling. In Type 2 Diabetes, cells begin to rely more on fatty acids and less on glucose for energy, a process that disrupts normal metabolic functions and contributes to insulin resistance. This shift is linked to changes in mitochondrial function, nutrient sensing pathways, and cellular signaling. Researchers are investigating ways to reverse this reprogramming by targeting key metabolic pathways to restore normal glucose metabolism and improve insulin sensitivity. Approaches like dietary interventions, exercise, and pharmacological agents aim to restore metabolic balance, offering potential new treatments for diabetes and related complications.

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